Title : Factor Xiiia-Positive Dendrocytes and Proliferative Activity of Cutaneous Cancers: Language : English: Author, co-author : Pierard-Franchimont, Claudine [Université de Liège - ULiège > > Dermatopathologie >]: Arrese Estrada, Jorge [Université de Liège - ULiège > > Dermatopathologie >]: Nikkels, Arjen [Université de Liège - ULiège > > Dermatologie >]

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Comparison of Angiomyofibroblastoma and Aggressive Angiomyxoma in Both Sexes: Four Cases Composed of Bimodal CD34 and Factor XIIIa Positive Dendritic Cell Subsets. Author links open overlay panel Jeffrey S. Silverman 1 2 Jak Albukerk 1 2 Ali Tamsen 1 2. Show more. Share. Cite.

100 Assays Factor XIIIa was seen in 29 (97%) of 30 DFs (mean factor-XIIIa score, 4.1 +/- 0.3). In contrast, 18 (75%) of 24 DFSPs stained for factor XIIIa (mean factor-XIIIa score, 1.3 +/- 0.2), but in most of these cases the factor-XIIIa-positive cells were felt to be entrapped nonneoplastic dermal dendrocytes. Factor Xiiia staining Four of 10 (40%) compound nevi, 9 of 20 (45%) radial growth-phase melanomas, and 12 of 20 (60%) vertical growth-phase melanomas showed an increase in factor Xllla staining of DDCs (Ta-ble 1). The majority of cases, with the exception of 3 vertical growth-phase melanomas, had only slight (1-I-) increased staining (Fig.

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Immunohistochemical analysis showed that factor XIIIa-positive histiocytic cells were distributed in the area without haemosiderin, but such cells were absent in the area with its deposition. Factor XIIIa-positive dermal dendritic cells and HLA-DR expression in radial versus vertical growth-phase melanomas. Fullen DR(1), Headington JT. Author information: (1)Department of Pathology, University of Michigan Hospitals, Ann Arbor, USA. Comment in J Cutan Pathol. 1999 May;26(5):263-4. Factor XIIIa Positive Control Slides suitable for immunohistochemistry (formalin-fixed, paraffin-embedded sections); find Sigma-Aldrich-251S MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich. Factor XIII or fibrin stabilizing factor is a zymogen found from the blood of humans and some other animals.

Download scientific diagram | On the immunohistochemical staining, there are positive reactions for Factor XIIIa and negative reaction for CD34 and desmin in 

Share. Cite. Factor XIIIA is the catalytic subunit and is a dimer of M.W. 160,000. According to studies, Factor XIII is present in plasma as an alpha2beta2 heterodimer (M.W.

17 Apr 2017 Blood coagulation factor XIII (FXIII) is a zymogen that circulates in FXIII, coagulation factor XIII; PE, pulmonary embolism; PPV, positive 

Factor xiiia positive

Numerous large, stellate cells in placental villi, decidua, and chorionic membranes also expressed factor XIIIa at 7–9 weeks gestational age, before the onset of fetal hematopoiesis. AFX showed sparse populations of FXIIIa+ cells in the stroma (mean score = 1.33 or 10-25% positive), which were distinct from the atypical giant cells characteristic of these tumors. Keloid similarly contained trapped FXIIIa+ cells (mean score = 0.44 or < 5% positive) that were distinct from the spindle-shaped fibroblasts of the tumor mass. The 'satellite fibroblasts' were factor XIIIa-positive similarly to dendrocytes and perineurial cells. Our study reveals the lack of specificity of CD68 antibody to identify macrophages. It also presents granular cell tumor of the skin as an exception in the group of schwannomas by the presence of factor XIIIa-positive cells inside the neoplasm. CD1a, CD35, CD45, CD68, factor XIIIa or S-100.

Factor xiiia positive

Positive control.
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Immunohistochemical analysis showed that factor XIIIa-positive histiocytic cells were distributed in the area without haemosiderin, but such cells were absent in the area with its deposition. Factor XIIIa-positive dermal dendritic cells and HLA-DR expression in radial versus vertical growth-phase melanomas.

Informed  site of factor XIIIa-catalyzed amine incorporation into p-casein, the most peptide studies to have a direct positive influence on the specificities of each of the  8 Feb 2018 Immunohistochemistry in Normal Skin: p63, EMA, desmin, SMA, CD34, Factor XIIIa.
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Factor xiiia positive






DF stains positively for Factor XIIIa and negative for CD34, while DFSP stains oppositely with positive CD34 staining and negative Factor XIIIa staining. This differentiation is, however, not absolute, as there are reports of Factor XIIIa positive DFSPs and of CD34 positive DFs.

[en] Factor XIIIa-positive dendrocytes present at the periphery and inside epithelial neoplasms are an heterogeneous group of cells. They are subsets of mesenchymal cells, cancer-associated macrophages and antigen-presenting cells.


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Factor XIIIa is a pan-histiocytic marker, similar to CD68.

They are subsets of mesenchymal cells, cancer-associated macrophages and antigen-presenting cells. Our results revealed that the dermis of patch- and plaque-stage KS lesions contains an increased number of factor XIIIa-positive dermal dendrocytes compared with normal dermis and that some of these cells are spindle shaped. Many of the spindle cells in patch- and plaque-stage lesions of KS, however, are negative for factor XIIIa. Comparison of Angiomyofibroblastoma and Aggressive Angiomyxoma in Both Sexes: Four Cases Composed of Bimodal CD34 and Factor XIIIa Positive Dendritic Cell Subsets Author links open overlay panel Jeffrey S. Silverman 1 2 Jak Albukerk 1 2 Ali Tamsen 1 2 Factor XIIIA is the catalytic subunit and is a dimer of M.W. 160,000. According to studies, Factor XIII is present in plasma as an alpha2beta2 heterodimer (M.W.