View 0 peer reviews of Glioma stem cells promote radioresistance by preferential activation of the DNA damage response on Publons Download Web of Science™ My Research Assistant : Bring the power of the Web of Science to your mobile device, wherever inspiration strikes.

1 Sep 2018 A consistent feature of the GSC and cancer stem cell DDR phenotype is the upregulation and/or constitutive activation of multiple components of both the DNA repair radiation resistance in relatively radiosensitive non-G

2017-10-09 · Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature 2006; 444 : 756–760. CAS Article Google Scholar In response to DNA damage, normal cells activate the DNA damage response (DDR), utilizing a variety of DNA damage sensing and repair pathways (e.g., base excision repair, nucleotide excision repair, homologous recombination, nonhomologous end-joining, mis-match repair, direct reversal) to maintain genomic integrity, whereas the inability to View 0 peer reviews of Glioma stem cells promote radioresistance by preferential activation of the DNA damage response on Publons Download Web of Science™ My Research Assistant : Bring the power of the Web of Science to your mobile device, wherever inspiration strikes. Glioma stem cells (GSCs) have a high capacity for self-renewal, invasion, and survival. How they communicate with each other to survive and maintain their identity is not clear.

PMID 17051156 : Anaplastic oligodendroglioma. Blakeley J, Grossman S. Glioblastoma remains the most common and devastating primary brain tumor despite maximal therapy with surgery, chemotherapy, and radiation. The glioma stem cell (GSC) subpopulation has been identified in glioblastoma and likely plays a key role in resistance of these tumors to conventional therapies as well as recurrent disease. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response.

Glioblastoma remains the most common and devastating primary brain tumor despite maximal therapy with surgery, chemotherapy, and radiation. The glioma stem cell (GSC) subpopulation has been identified in glioblastoma and likely plays a key role in resistance of these tumors to conventional therapies as well as recurrent disease.

Bao S, Wu Q, McLendon RE, Hao Y, Shi Q, Hjelmeland AB, Dewhirst MW, Bigner DD, Rich JN. Nature. 2006 Dec 7;444(7120):756-60. Epub 2006 Oct 18.

igenicity of experimental glioma-derived cancer initiating cells by preventing mainly due to the redundancy of the pathways as well as co-activation of the tyrosine kinases. mosomes becomes highly unstable and trigger the DNA damage response in Glioma stem cells promote radioresistance by preferential activation

Glioma stem cells promote radioresistance by preferential activation of the dna damage response

In this article, Singh and colleagues undertook a comparative evaluation of pre-clinical efficacy and safety of three immunotherapeutic modalities directed against CD133 braintumor-initiating cells. While all three modalities were efficacious in orthotopic GBM xenografts, CD133-specific CAR-T cells represented the most therapeutically tractable strategy against functionally important CD133 Bao S, Wu Q, McLendon RE, et al. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature. 2006; 444 (7120):756–760. They concluded that CD133 + cells can activate DNA damage checkpoint responses to a greater degree than CD133 − cells and thus repair DNA damage more efficiently. Intriguingly, by using an inhibitor of the checkpoint kinases Chk1 and Chk2, they were able to radiosensitize the CD133 + cells.

Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. 2019-08-27 · Glioma stem cells promote radioresistance by preferential activation of the DNA damage response Nature , 444 ( 2006 ) , pp. 756 - 760 CrossRef View Record in Scopus Google Scholar Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Shideng Bao, et al., Nature, 444:756 (2006) Speaker : non-stem glioma cells due to preferential activation of the DNA damage response pathway [7]. Other groups also reported that the cancer stem cells of breast cancers were rela-tively resistant to radiation, potentially due to lower levels of reactive oxygen species found in cancer stem cells [14].
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Analysen är baserad på stamcells differentiering reporter varvid uttrycket av den förbättrade GFP Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. neuromuscular blocking agents promote astroglial differentiation and deplete glioblastoma stem cells. igenicity of experimental glioma-derived cancer initiating cells by preventing mainly due to the redundancy of the pathways as well as co-activation of the tyrosine kinases.

The fraction of tumour cells expressing CD133 (Prominin-1), a marker for both neural stem cells and brain cancer stem cells, is enriched after radiation in gliomas. Here we show that cancer stem cells contribute to glioma radioresistance through preferential activation of the DNA damage checkpoint response and an increase in DNA repair capacity.
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Glioma stem cells promote radioresistance by preferential activation of the DNA damage response

DNA damage checkpoint response of glioblastoma stem cells through NBS1 that GBM stem cells (GSCs) display a preferential activation of DNA damage promote radioresistance through preferential activation of the DNA damage . 24 Mar 2021 Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature.

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Neoplastic Stem Cells Subject Areas on Research 4-Hydroperoxycyclophosphamide purging of breast cancer from the mononuclear cell fraction of bone marrow in patients receiving high-dose chemotherapy and autologous marrow support: a phase I trial.

In both cell culture and the brains of immunocompromised mice, CD133-expressing glioma cells survive ionizing radiation in increased proportions Here we show that cancer stem cells contribute to glioma radioresistance through preferential activation of the DNA damage checkpoint response and an increase in DNA repair capacity. The fraction of tumour cells expressing CD133 (Prominin-1), a marker for both neural stem cells and brain cancer stem cells, is enriched after radiation in gliomas. Here we show that cancer stem cells contribute to glioma radioresistance through preferential activation of the DNA damage checkpoint response and an increase in DNA repair capacity. The fraction of tumour cells expressing CD133 (Prominin-1), a marker for both neural stem cells and brain cancer stem cells, is enriched after radiation in gliomas. Ionizing radiation represents the most effective therapy for glioblastoma (World Health Organization grade IV glioma), one of the most lethal human malignancies, but radiotherapy remains only palliative because of radioresistance. The mechanisms underlying tumour radioresistance have remained elusive. Here we show that cancer stem cells contribute to glioma radioresistance through preferential activation of the DNA damage checkpoint response and an increase in DNA repair capacity.